Understanding IMSI Treatment
Learn from our experts and get inspired by real patient journeys
ADVANCED IMSI FERTILITY TREATMENT
IMSI Treatment in Ahmedabad
IMSI treatment in Ahmedabad offers advanced sperm selection using high-magnification technology to improve fertilization outcomes. At Wellspring IVF, we identify subtle sperm abnormalities and create personalized treatment plans to increase your chances of a successful pregnancy.
✓ Medically reviewed by Dr. Pranay Shah, MS (ObGy)
Treatment Overview
Infertility Causes & Conditions — A Shared Diagnosis
One year. That is usually the threshold. If you have been trying to conceive for twelve months without success — or six months if you are over 35 — the medical term is infertility. But the word itself is misleading. It carries a finality that the clinical reality simply does not support.
Infertility is a diagnosis of cause — not of outcome. In the vast majority of cases, there is a specific, identifiable reason why conception has not occurred. And in the vast majority of those cases, that reason is treatable.
The first step — and the step that most couples delay far too long — is investigation. Not assumption. Not internet research. Not waiting another year. Investigation — of both partners, simultaneously, systematically.
At Wellspring IVF & Women’s Hospital, Dr. Pranay Shah approaches every couple as a unit. Not as a woman with a problem, and a man who waits. As two people sharing one diagnosis — with one shared goal.
Infertility Is a Shared Diagnosis — The Numbers
When couples struggle to conceive, the instinct is to focus on the woman. Scans are arranged for her. Blood tests are ordered for her. Months pass. This is the single most common and most costly mistake in fertility medicine:
35%
Female Factor
Ovulation, tubal, uterine, or ovarian reserve cause identified in the woman
35%
Male Factor
Sperm count, motility, or DNA issue identified in the man
30%
Combined or Unexplained
Both partners have contributing factors, or no single cause found despite full investigation
What this means for you: There is a 65% chance that the male partner is the sole or contributing cause of your difficulty conceiving. A semen analysis costs a fraction of any female fertility investigation — and can be completed in under an hour. At Wellspring IVF, we investigate both partners from Day 1.
IUI vs IVF — Understanding the Decision Framework
The most common question Dr. Shah receives from couples considering treatment is: 'Should we start with IUI or go straight to IVF?' The honest answer depends on your specific diagnosis — not a default protocol. This table makes the clinical decision framework transparent:
Female Infertility — Causes & Conditions
Difficulty conceiving, irregular periods, hormonal issues, previous diagnosis, or unexplained failure after IVF — start here.
- PCOD / PCOS — Hormonal & Ovulation Disorder
- Endometriosis — Tissue Growing Outside the Uterus
- Adenomyosis — Uterine Lining in the Muscle Wall
- Blocked Fallopian Tubes — Tubal Factor Infertility
- Low AMH / Poor Ovarian Reserve
- Uterine Fibroids — Location Matters More Than Size
- Uterine Polyps — Endometrial Polyps & Implantation
- Recurrent Miscarriage — Causes & Management
- Go to Female Infertility Hub — Causes, Diagnosis & Treatment
Male Infertility — Causes & Conditions
Semen analysis result, low count, zero sperm, motility concerns — or never been tested at all. Start here.
- Azoospermia — Zero Sperm Count (Nil Sperm)
- Oligospermia — Low Sperm Count Treatment
- Poor Sperm Motility — Asthenospermia
- Sperm DNA Fragmentation — The Hidden Cause
- Unexplained Male Infertility — Normal Semen, Still Failing
- Go to Male Infertility Hub — Semen Analysis, Diagnosis & Treatment
Symptom Navigator — Start With What You've Noticed
If you are unsure where to begin, use this table to match your primary concern to the most likely investigation path:
| What You've Noticed | Most Likely Investigation | Go To |
|---|---|---|
| Irregular or absent periods, weight gain, acne | Hormonal panel, TVS for PCOS | PCOD/PCOS → |
| Severe period pain, pain during sex | Laparoscopy for Endometriosis | Endometriosis → |
| Heavy bleeding, painful periods, bulky uterus | TVS/MRI for Adenomyosis or Fibroids | Adenomyosis → |
| No symptoms + history of infection, TB, or prior surgery | HSG / Hysteroscopy for Blocked Tubes | Blocked Tubes → |
| Age >35 or short cycles, prior ovarian surgery | AMH test + AFC scan | Low AMH → |
| 2+ miscarriages, recurrent IVF failure | Thrombophilia panel, uterine cavity assessment | Recurrent Miscarriage → |
| Semen analysis: low count or zero sperm | WHO semen analysis, hormonal panel, Doppler | Male Infertility → |
| Normal semen analysis but repeated IVF failure | Sperm DNA Fragmentation (DFI) test | Sperm DNA → |
| Both partners tested — all results normal | Unexplained infertility workup, ERA test | Contact Dr. Shah → |
When Should You Seek Help?
The guidance below is based on clinical evidence. Waiting is a valid choice — but waiting longer than these thresholds without investigation is not clinically advisable:
| Situation | When to Consult a Fertility Specialist |
|---|---|
| Under 35, regular cycles, no known issues | After 12 months of unprotected regular intercourse without conception |
| 35–37 years of age | After 6 months of trying — do not wait 12 months |
| Over 38 years of age | Start investigation immediately — even before trying for 3 months |
| Irregular or absent periods (PCOS, thyroid) | Seek evaluation before starting to try — do not delay |
| Known endometriosis, fibroids, or prior surgery | Consult before trying — pre-treatment may improve chances significantly |
| Known male factor (previous semen report) | Seek specialist evaluation immediately — time matters |
| 2 or more pregnancy losses (any gestation) | Investigation after 2 losses — do not wait for a third |
| Any prior IVF failure | Seek a second opinion with full cycle review — do not repeat blindly |
Fresh vs. Frozen Embryo Transfer: Which Has Higher Success?
Fresh vs. Frozen Embryo Transfer: Which Has Higher Success?
Fresh vs. Frozen Embryo Transfer: Which Has Higher Success?
Fresh vs. Frozen Embryo Transfer: Which Has Higher Success?
The Wellspring IVF Approach — Both Partners, Day One
The single most important difference in Dr. Pranay Shah’s approach is the one that couples feel from their very first appointment: both partners are investigated at the same time.
This sounds obvious. In practice, it rarely happens. Across India, fertility workups are still initiated almost exclusively on the female partner. The male partner enters the picture — often only for a semen test — weeks or months into the process. By this time, the couple has already undergone scans, blood tests, and sometimes procedures, without knowing whether the primary factor is male.
At Wellspring IVF, the first consultation ends with investigation orders for both partners. The semen analysis result is available the same day. The female hormonal panel returns within 24–48 hours. By the second consultation, we have a complete picture — and a real plan.
What Happens at Your First Consultation at Wellspring IVF
- Complete history for both partners: Duration of trying, previous pregnancies, prior treatments, surgical history, medications, lifestyle factors.
- Semen analysis for the male partner: Produced privately at our andrology lab. Count, motility, morphology, volume. Report ready within the same appointment or same day.
- Day 2–3 hormonal panel for the female partner: FSH, LH, AMH, Oestradiol, TSH, Prolactin. AMH gives us an immediate read on ovarian reserve.
- Transvaginal ultrasound (TVS): Antral follicle count, uterine assessment, ovarian morphology (PCOS screening), any obvious structural findings.
- Treatment plan presented: At the follow-up consultation with all results in hand, Dr. Shah presents a clear, personalised plan — with full explanation of what was found and why each step is recommended.
What Our Patients Say
Real stories from real families who trusted us with their fertility journey
After 5 years of marriage and visiting many places, when we came here, we decided on the right guidance here that we will get the ivf procedure done from here, today we have 10 days of treatment. Due to the convenience, arrangement and facility o...
My experience with wellspring hospital is very good .their staff is very supportive. Dr. Pranay is very good and professional.100% transparency at every stage. No last minute surprises.Once again thank you so much to the all team. Highlly recomme...
Wellspring IVF & women hospital is one of the best IVF center in India where me like other infertile Indian and foreigner couples fulfill their dreams of having a healthy baby.Dr Pranay Shah has deep knowledge and skill in his work with positive ...
Such a nice experience at well spring. And we get A childhope from this well spring hospital. Thanks a lot all members of hospital and specially to Dr. Pranay Shah sir
This is one of the best ivf clinic in Ahemdabad, Dr.Pranay shah and his team are highly professional and knowledgeable, and his staff members are too good and supportive. Dr. Pranay shah is result oriented and confident, and gives right instructi...
We were facing some difficulties related pregnancy and we got reference of Wellspring Hospital. We thank God that we found such a talented and knowledgeable Dr. Pranay Sir. The most thing we like about him is the way of treatment he follows. I str...
I've been blessed with two daughters by the treatment given by Dr. Pranay Shah the services given to me were comforting and caring.
This is one of the best hospital in ivf treatment with highest possibility of success, best supportive doctor and staff, thanks and recommended all to visit once
No words are enough to express my gratitude . Thank you for making our dream comes true. You are extraordinary doctor as well as extraordinary human being also.Again thank you so much Dr.Pranay Shah and your team. Best ever doctor I have meet in ...
Great experience with great doctor and very supportive after care facilities. Dr. Shah was not only helpful with numerous questions that we asked for around 6 months before we started the treatment but is also helping us now. He has been very help...
We were looking for a good fertility center we came across some good reviews of Wellspring Spring Ivf Hospital. We decided and visited the hospital and with in no time the process was completed and in first attempt only the result was positive?. ...
It has been one of the best choices that I could have made. Since researching Wellspring on Google till now the end of complete IVF cycle it has been a wonderful experience. I could have gone to biggies referential IVF Centres but I am sure experi...
We had been very desperate to have a child. Visited many IVF centers in India for treatment. But did not get any positive result. Visited the Best IVF Center in Ahmedabad Wellspring IVF and Women's hospital after seeing good reviews. Happy to sa...
Wellspring IVF & Women's Hospital is best IVF Center in Ahmedabad. Best thing, we got positive result in Fist IVF Cycle. Second best thing, Doctor has told us exact amount of Cost of each IVF Cycle before start of treatment so there would be no en...
Me and my husband are very glad we chose to come here for treatment. I would highly recommend Dr. Shah and his team at the Wellspring IVF and Women's hospital to anyone wanting to reach their dream of becoming parents. His medical knowledge and p...
No words are enough to express my gratitude . Thank you for making our dream comes true. You are extraordinary doctor as well as extraordinary human being also.Again thank you so much Dr.Pranay Shah and your team.
Excellent IVF Center. Friendly nature all staff & Doctor. Excellent Treatment for the Doctor. Thanks Wellspring IVF Fullfil our Dreams.
What to say about dr pranay sir Very good human being along with very good doctor Always showers positivity on us Solves every small small queries with open heart and big smile Approachable 24*7 I will suggest everyone to consult at least once if ...
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What Is Unexplained Infertility?
Approximately 10–15% of couples complete a full fertility workup and receive results within the normal range for both partners. This is classified as "unexplained infertility" — and it is one of the most frustrating diagnoses in medicine. However, "unexplained" does not mean "untreatable." It most commonly means that standard tests have not captured a subtle issue. Advanced investigations available at Wellspring IVF include:
Normal semen analysis but high DNA damage — a common hidden cause of IVF failure.
Tests whether the uterine lining is receptive to embryo implantation at the precise time of transfer — a personalised implantation window test.
Direct visual inspection of the uterine cavity. Subtle polyps, synechiae (adhesions), or endometritis (uterine infection) are not always visible on ultrasound.
For recurrent implantation failure — certain clotting disorders impair blood flow to the developing embryo.
Screens embryos for chromosomal abnormalities before transfer. Identifies embryos most likely to implant and least likely to miscarry.
Frequently Asked Questions
Find answers to common questions about IMSI, nuclear vacuoles, DFI, and how IMSI differs from standard ICSI.
Ask a QuestionHow do we know whether the problem is with me or my husband?
You find out by testing both of you — simultaneously. At Wellspring IVF, the first consultation ends with investigation orders for both partners. The semen analysis is available the same day. The female hormonal panel within 24–48 hours. Within one week of your first appointment, Dr. Shah typically has enough information to identify the primary factor — whether it is female, male, or both.
We have been trying for 8 months. Is it too early to see a doctor?
If you are under 35, the standard guideline is 12 months before seeking help. However, there are important exceptions: if you have irregular periods, known PCOS, any prior pelvic surgery, or any history of infection — do not wait 12 months. And if you are over 35, 6 months is the threshold. There is no harm in consulting earlier — a good specialist will simply reassure you and monitor, not rush you into treatment.
All our tests are normal but we still cannot conceive. What is wrong?
This is ‘unexplained infertility’ — affecting approximately 10–15% of couples. Standard tests are genuinely normal. The next step is advanced investigation: sperm DNA fragmentation, ERA (endometrial receptivity), hysteroscopy, and a thrombophilia panel. In the majority of unexplained cases, one of these advanced tests reveals the answer.
Can stress cause infertility?
Chronic, severe stress can disrupt the hypothalamic-pituitary-ovarian axis — the hormonal signalling chain that drives ovulation — and may suppress sperm production in men. However, stress is very rarely the primary cause of clinical infertility. The advice to ‘just relax’ has caused enormous harm to couples who had treatable conditions that went uninvestigated for years because they were told to reduce stress first. If you have been trying for the appropriate duration without success, get investigated — regardless of your stress levels.
Is IVF the only treatment option for infertility?
No — and in many cases, it is not even the first option. IVF is indicated for specific diagnoses: blocked tubes, severe male factor, IUI failure, advanced age with time constraints, or complex combined factors. For many other diagnoses — mild PCOS, mild male factor, ovulation disorders, correctable uterine issues — treatment with medication, lifestyle change, or IUI is appropriate first. Dr. Shah’s approach is to use the minimum necessary intervention for each specific diagnosis.
Does age really matter that much for fertility?
For female fertility — yes, significantly. A woman is born with her entire lifetime supply of eggs. Egg number (ovarian reserve) and egg quality both decline with age — the decline accelerates meaningfully after 35 and sharply after 38. For men, age also matters, but the decline is more gradual. This is why we recommend earlier consultation for women over 35, and why we always check AMH (Anti-Müllerian Hormone) at the first appointment — it gives an accurate, age-independent measure of ovarian reserve.
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The Answer Exists.
In most cases, infertility has a specific, identifiable cause.
The investigation that finds it — for both partners — takes one week. Book a consultation with Dr. Pranay Shah and begin with answers, not assumptions.
The investigation that finds it — for both partners — takes one week. Book a consultation with Dr. Pranay Shah and begin with answers, not assumptions.